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Target intelligence / Profile preview
Urokinase-type Plasminogen Activator Receptor (uPAR)
- Target
- uPAR
- Molecular classification
- Receptor, GPI-anchored cell surface receptor
01
Overview
Urokinase-type Plasminogen Activator Receptor (uPAR) is a GPI-anchored cell surface receptor that binds urokinase-type plasminogen activator (uPA), localizing it to the cell surface and facilitating the conversion of plasminogen to plasmin. This process is crucial for extracellular matrix (ECM) degradation during tissue remodeling, wound healing, and cancer metastasis. uPAR interacts with integrins and activates intracellular signaling pathways, regulating proliferation, survival, migration/invasion, and angiogenesis. It is highly expressed in many malignant tumors and elevated suPAR levels are biomarkers for chronic inflammatory diseases.
- Other names
- CD87PLAUR
02
Mechanism of action
Monoclonal antibodies targeting uPAR; Gene therapy approaches; Nanoparticles/nanoplatforms carrying drugs or photodynamic/photothermal agents.
03
Biological functions
Tissue remodelingWound healingMammary gland involutionCell migrationCell adhesionCell cycle regulationApoptosisPlasminogen activationExtracellular matrix degradation
04
Disease associations
CancerInflammationChronic Obstructive Pulmonary Disease (COPD)AsthmaLiver failureHeart failureCardiovascular diseaseRheumatoid arthritis
05
Biomarkers
Soluble uPAR (suPAR)
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