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Target intelligence / Profile preview
Uroplakin-1b (UPK1B)
- Target
- UPK1B
- Molecular classification
- Tetraspanin family (Transmembrane 4 superfamily), Cell surface structural protein, Integral membrane protein
01
Overview
Uroplakin-1b (UPK1B) is a tetraspanin family integral membrane protein that is a structural component of the asymmetric unit membrane (AUM) forming plaques on the apical surface of urothelial cells in the bladder and kidney. These plaques contribute to the permeability barrier of the urothelium, maintaining structural integrity during bladder distension and protecting superficial cells from urine exposure. UPK1B plays a vital role in urothelial differentiation, tissue development, and homeostasis, and loss or dysregulation of UPK1B leads to urothelial plaque disruption, altered cell composition, dysplasia, and congenital anomalies of the urinary tract. UPK1B is not a classical drug target (such as a receptor, enzyme, or transporter), but it is relevant as a disease marker and as a structural protein essential for urinary tract biology.
- Other names
- Uroplakin 1BUPK1BUP1bTSPAN20UPIbTetraspanin-20Uroplakin IbUPIBUPK1tetraspanTspan-20tetraspanin-20
02
Biological functions
Formation and stabilization of asymmetric unit membrane (AUM) plaques in the apical surface of urotheliumRegulation of membrane permeability in bladder umbrella cellsMaintenance of urothelial structure and homeostasisSignaling in cell differentiation, activation, growth, motilityInvolvement in urinary tract and kidney development
03
Disease associations
Structural and functional defects of urinary tract (including congenital anomalies of kidney and urinary tract—CAKUT)Urothelial dysplasia (precursor of bladder carcinoma)Cancer (bladder cancer, transitional cell carcinoma)
04
Safety considerations
Potential link of UPK1B dysregulation to urothelial dysplasia and risk of carcinomaDisruption can cause urinary tract developmental defects and homeostatic loss
05
Biomarkers
Marker for urothelial differentiation and urothelial plaquesDysplasia and loss can indicate precursor states of bladder cancer
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