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Target intelligence / Profile preview
Urotensin-II-related peptide (UTS2B)
- Target
- UTS2B
- Molecular classification
- Peptide ligand, Neurohormone, Secreted precursor protein
01
Overview
Urotensin-II-related peptide (Urotensin 2B, UTS2B, also known as URP) is a secreted peptide ligand, primarily expressed in the central nervous system and peripheral tissues, where it binds and activates the urotensin-II receptor, a G protein-coupled receptor involved in vasoconstriction, blood pressure regulation and neuroendocrine signaling. While closely related to urotensin-II, UTS2B is encoded by a distinct gene and has overlapping but not identical distribution and regulatory functions. Unlike the receptor (UT, GPR14), UTS2B itself is not a therapeutic target, but rather a ligand for the UT receptor, which is the pharmacological focus of drug development efforts[1][2][3].
- Other names
- Urotensin-2BUTS2BURPUTS2DU-IIBUIIBU2BUrotensin II-related peptideUrotensin IIBUrotensin-2 domain-containing proteinprepro-URPurotensin-2B
02
Mechanism of action
Acts as an agonist at the Urotensin-II receptor (UT), activating Gq/11 and triggering intracellular calcium mobilization and protein kinase C pathways (for receptor, not the peptide)[1][2]
03
Biological functions
G protein-coupled receptor bindingRegulation of blood pressure[3]Signal transductionPossible involvement in smooth muscle contraction and neuroendocrine signaling[1][2]
04
Disease associations
Cardiovascular diseasePossible roles in hypertension, heart failure, and metabolic syndrome[1][2]
05
Safety considerations
None reported for the peptide itself; modulation of the UT receptor may have concerns related to vascular tone and blood pressure[1]
06
Interacting drugs
None directly; acts as ligand for the Urotensin-II receptor, which is a drug target[1][2]
07
Biomarkers
None established for patient selection or efficacy monitoring
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