Target intelligence / Profile preview

Urothelial carcinoma associated 1 (UCA1)

Target
UCA1
Molecular classification
Long non-coding RNA, Other
01

Overview

Urothelial carcinoma associated 1 (UCA1), encoded by the ENSG00000273782 gene, is a long non-coding RNA (lncRNA) that is not translated into a protein. It has been studied primarily in the context of cancer, particularly urothelial carcinoma, where it is often upregulated and plays a role in regulation of gene expression linked to cancer cell growth and invasion. UCA1 does not encode a classical protein "target" such as a receptor, enzyme, transporter, or ion channel, and it is not directly targeted by therapeutic drugs. Its functions are related to noncoding RNA regulation—generally modulation of gene expression, interactions with other RNAs or proteins, and possibly acting as a biomarker for cancer diagnosis or prognosis[1][7]. ENSG00000273782 encodes Urothelial carcinoma associated 1 (UCA1), a long non-coding RNA with regulatory functions, notably in cancer, but is not considered a direct therapeutic target such as a receptor or enzyme[7][1].

Other names
UCA1ENSG00000273782
02

Biological functions

Regulation of gene expressionOther
03

Disease associations

CancerOther
04

Safety considerations

Although associated with cancer, there is no evidence of direct safety concerns related to targeting this RNA; rather, research targets its expression as part of understanding cancer biology.
05

Biomarkers

UCA1 is a biomarker in the context of cancer and has been explored as a diagnostic and prognostic marker, particularly in urothelial and other cancers

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