USP46 antisense RNA 1 (USP46-AS1)

USP46 antisense RNA 1 (USP46-AS1, also called USP46 divergent transcript or USP46-DT) is a long non-coding RNA (lncRNA) transcribed from the region antisense to the **USP46** gene. Unlike proteins such as receptors or enzymes, USP46-AS1 does not encode a protein but may regulate gene expression through RNA–RNA interactions, chromatin remodeling, or transcriptional interference. Antisense lncRNAs like USP46-AS1 can modulate expression of their associated protein-coding gene (in this case, USP46, a deubiquitinating enzyme involved in synaptic function and tumor suppression), but for USP46-AS1 itself, functional characterization is limited, and it is not considered a standalone therapeutic target or conventional receptor/enzyme. Research into antisense RNAs suggests they may be generally important in cellular regulatory processes, but USP46-DT has not been specifically implicated in human disease or therapy development to date[3]. **Note:** - USP46-AS1 is distinct from **USP46** itself, which is a well-characterized deubiquitinating enzyme relevant to synaptic function and some disease processes[1][2][5]. The antisense RNA described here is a regulatory RNA overlapping the USP46 gene and should not be confused with the protein-coding gene or its protein product. - There is nothing incorrect about the target name or classification, but "USP46 divergent transcript" is not a druggable or classical therapeutic target.

Other names

USP46 divergent transcriptUSP46-DTCTD-2314I6.1USP46 antisense RNA 1 (non-protein coding)