USP8 pseudogene 1 (USP8P1)

USP8P1, also known as "ubiquitin specific peptidase 8 pseudogene 1," is a pseudogene related to the USP8 gene family. Pseudogenes are segments of DNA that resemble known genes but are nonfunctional; they do not produce an active protein product. While the parental gene USP8 is a catalytically active deubiquitinating enzyme involved in protein trafficking, endosomal sorting, and regulation of receptor turnover (and is considered a potential therapeutic target in cancer and endocrine diseases), USP8P1 lacks essential genetic elements for expression or function. USP8P1 is not a therapeutic target, unlike USP8. It is frequently listed in gene databases as a nonfunctional genomic element associated with the USP8 gene. USP8P1 is a pseudogene, not an active protein or molecular target. Queries regarding its role as a receptor, enzyme, or drug target are based on a misinterpretation. Functional USP8 (not USP8P1) is a ubiquitin-specific peptidase (deubiquitinase) implicated in endosomal sorting, signal transduction, and certain diseases such as Cushing's disease, cancers, and resistance to immunotherapies. The pseudogenes (including USP8P1) may share sequence homology but have no established biological roles, drug interactions, or relevance as disease biomarkers. USP8P1 is not a protein-coding gene nor a therapeutic target; it is a pseudogene that does not encode a functional enzyme or receptor, and therefore, has no known biological function, disease association, or relevance to drug targeting. The interpreted query concerns a nonfunctional genetic element, not a targetable molecule.

Other names

KIAA0055-homD84394.7USP8Pubiquitin specific peptidase 8 pseudogene 1ubiquitin specific protease 8 pseudogeneUSP8P1