USP9Y pseudogene 25 (USP9YP25)

USP9Y pseudogene 25 (USP9YP25) is a non-functional genetic element on the Y chromosome, classified as a pseudogene[1][6]. It is homologous to USP9Y, which encodes a peptidase involved in spermatogenesis[3][4][5]. However, USP9YP25 itself does not encode an active enzyme and has no known biological function, therapeutic relevance, or role in disease[1][6]. Pseudogenes like USP9YP25 are common in the genome; they are considered evolutionary remnants without protein products or direct regulatory roles[6]. Key distinction: USP9YP25 must not be confused with the active gene USP9Y (ubiquitin specific peptidase 9, Y-linked)[4][5], which indeed is a protein-coding gene with a role in spermatogenesis and male infertility[3][4][5]. USP9YP25 instead is a non-functional pseudogene with no current biomedical significance.

Other names

ubiquitin specific peptidase 9, Y-linked pseudogene 25USP9YP25