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Target intelligence / Profile preview
Uterine Smooth Muscle (USM)
- Target
- USM
- Molecular classification
- Smooth Muscle Tissue, Tissue
01
Overview
Uterine smooth muscle, or myometrium, is the muscular layer of the uterus responsible for contractions during menstruation, pregnancy, and labor. Its function is regulated by hormones (estrogen, progesterone), calcium signaling, and various other factors. Abnormalities in myometrial function can lead to conditions like preterm labor, infertility, or postpartum hemorrhage.
- Other names
- MyometriumUterine Smooth Muscle Cells (USMCs)
02
Mechanism of action
Varies depending on the interacting drug. For example, oxytocin stimulates uterine contractions via Gq protein-coupled receptors, while tocolytics inhibit contractions via various mechanisms (calcium channel blockade, beta-adrenergic receptor agonism, etc.)
03
Biological functions
ContractionMaintenance of uterine toneMenstruationLaborPostpartum hemostasis
04
Disease associations
Preterm laborInfertilityDysmenorrheaPostpartum hemorrhageUterine fibroids (leiomyomas)Endometriosis
05
Safety considerations
Tocolytic use can have cardiovascular side effects (e.g., tachycardia, hypotension).Oxytocin can cause uterine hyperstimulation or rupture.Ergot alkaloids can cause vasoconstriction and hypertension.Drug interactions with other medications affecting smooth muscle function.
06
Interacting drugs
Oxytocin
4 more in the full profile.
07
Biomarkers
Intracellular Calcium ConcentrationElectrophysiological parameters (resting membrane potential, slow wave activity)Smooth muscle actin expressionHormone receptor expression (estrogen receptor, progesterone receptor)Connexin 43 expression (gap junction protein)Prostaglandin levelsOxytocin receptor expression
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