UTP11 small subunit processome component (UTP11)

UTP11 small subunit processome component is an RNA-binding nucleolar protein involved in the biogenesis of the 18S ribosomal RNA by binding pre-rRNA processing factor MPP10. It is a critical component of the small subunit (SSU) processome, a ribosome assembly intermediate. UTP11 is overexpressed in diverse human cancers and correlates with poor prognosis. UTP11 depletion triggers nucleolar stress, which activates p53 signaling and arrests cancer cell growth. Additionally, UTP11 regulates NRF2-dependent ferroptosis, independent of p53, contributing to its role as an oncogenic protein. Targeting UTP11 may provide an attractive strategy for cancer therapy by inducing cell death through nucleolar stress and ferroptosis

Other names

UTP11LProbable U3 small nucleolar RNA-associated protein 11UTP11 small subunit processome component2700082D03RikCGI-94LOC51118RGD1559610

- Induction of nucleolar stress leading to p53 activation and cancer cell growth arrest - Promotion of ferroptosis via destabilization of NRF2 mRNA and repression of SLC7A11 - Disruption of ribosome biogenesis (inhibiting 18S rRNA synthesis)