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Utrophin (UTRN)
- Target
- UTRN
- Molecular classification
- Cytoskeletal protein
01
Overview
Utrophin is a cytoskeletal protein structurally and functionally similar to dystrophin. It anchors the cytoskeleton to the plasma membrane and is upregulated in Duchenne Muscular Dystrophy (DMD) as a compensatory mechanism. Therapeutic strategies aim to further upregulate utrophin to stabilize muscle cell membranes in the absence of functional dystrophin.
- Other names
- DMDLDRPDRP1utrophin
02
Mechanism of action
Upregulation of utrophin to compensate for dystrophin deficiency in Duchenne Muscular Dystrophy.
03
Biological functions
Cytoskeletal anchoringReceptor clusteringMaintains membrane integrity
04
Disease associations
Duchenne Muscular Dystrophy (therapeutic target)
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