UV excision repair protein RAD23 homolog A (RAD23A)

UV excision repair protein RAD23 homolog A (RAD23A) is a multifunctional DNA repair factor implicated in the nucleotide excision repair (NER) pathway, responsible for recognizing and repairing bulky lesions in DNA such as those induced by ultraviolet light. RAD23A contains a modular domain structure with an N-terminal ubiquitin-like (UbL) domain, ubiquitin-associated (UbA) domains, and an XPC-binding segment, allowing it to bind single-stranded DNA, interact with polyubiquitin chains, and stabilize the XPC repair complex. Through association with the 26S proteasome and diverse polyubiquitinated substrates, RAD23A participates in maintaining genome stability and regulating protein homeostasis via the ubiquitin-proteasome system. RAD23A is expressed in numerous human tissues and is evolutionarily conserved across species, including yeast and insects. Defects or dysregulation in its pathway are implicated in DNA repair disorders such as xeroderma pigmentosum, and dysregulated repair may contribute to cancer and other diseases involving genomic instability.

Other names

HR23AhHR23AHHR23AMGC111083RAD23yeast homolog ARAD23 homolog Anucleotide excision repair protein RAD23A

Not applicable (as no drugs directly target this protein; however, RAD23A assists in DNA repair processes and protein degradation via the ubiquitin-proteasome system).