UV-stimulated scaffold protein A (UVSSA)

UV-stimulated scaffold protein A (UVSSA) is a human DNA repair protein critical for the transcription-coupled nucleotide excision repair (TC-NER) pathway, which specifically addresses UV-induced DNA lesions blocking RNA polymerase II during transcription[3][1][4][5][6][7]. UVSSA stabilizes Cockayne syndrome B protein (CSB) by recruiting the deubiquitinating enzyme USP7 to repair complexes and prevents degradation of repair proteins by the proteasome[1][3][5]. Loss-of-function mutations in the UVSSA gene cause UV-sensitive syndrome, a rare autosomal recessive disorder characterized by hypersensitivity to UV light and deficiency in repair of transcription-blocking DNA damage[3][5]. This protein is essential for clearing RNA polymerase II-blocking lesions, and its absence leads to impaired DNA repair and aberrant recovery of transcription after UV irradiation[5][3]. UVSSA does not have known direct small molecule modulators or recognized use as a classical therapeutic target, such as a receptor, transporter, or enzyme[3][7][4].

Other names

KIAA1530UVSS3UVSSA_HUMANH0Y924Q2YD98H0Y924phH0Y924