Vγ9Vδ2 T Cell Activation

Activation of human Vγ9Vδ2-T lymphocytes involves recognition of non-peptide phosphoantigens presented by butyrophilin molecules independently from classical MHC pathways. Upon activation, these versatile immune effectors mediate cytolytic activity against infected/malignant targets through multiple mechanisms—including direct killing, cytokine release, ADCC—and modulate broader immune responses. Their unique biology underpins current interest in harnessing them for novel immunotherapies targeting cancer and infectious diseases.

Other names

Vgamma9Vdelta2 T Cell Activationγδ T cell activationVγ9Vδ2-T lymphocyte activation

Activation of Vγ9Vδ2 T cells through TCR recognition of phosphoantigens presented by butyrophilins, leading to downstream effector functions such as cytotoxicity and cytokine release.