Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
V-set and Immunoglobulin Domain Containing 4 (VSIG4)
- Target
- VSIG4
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane protein, B7 family-related, Complement receptor, Immune checkpoint molecule
01
Overview
VSIG4 is a type I transmembrane protein belonging to the immunoglobulin superfamily. It functions as both an immune checkpoint molecule and a complement receptor, primarily expressed by tissue-resident macrophages. It binds complement fragments C3b and iC3b, mediating phagocytosis and inhibiting the alternative complement pathway. VSIG4 negatively regulates T-cell activation. Urinary VSIG4 shows promise as a biomarker for lupus nephritis.
- Other names
- CRIgZ39IG
02
Mechanism of action
Negative regulation of T-cell activation by engagement with its ligand(s); Mediates phagocytosis of C3b/iC3b-opsonized pathogens.
03
Biological functions
Complement bindingPhagocytosisImmune regulationT-cell inhibitionModulation of complement pathway
04
Disease associations
Autoimmune diseasesLupus nephritisSystemic lupus erythematosusInflammationParkinson's DiseaseAtherosclerosis
05
Safety considerations
Potential for broad immunosuppression if targeted systemically
06
Biomarkers
Urinary VSIG4 (free and immune complex-bound) for lupus nephritis diagnosis and activity monitoring
Beyond the preview
Go deeper on V-set and Immunoglobulin Domain Containing 4 (VSIG4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on V-set and Immunoglobulin Domain Containing 4 (VSIG4).