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Target intelligence / Profile preview
V-set and immunoglobulin domain-containing protein 4 (VSIG4)
- Target
- VSIG4
- Molecular classification
- B7 family-related, Immunoglobulin superfamily, Type I transmembrane protein, Complement receptor, Immune checkpoint molecule
01
Overview
VSIG4 (V-set and immunoglobulin domain-containing protein 4), also known as CRIg, is a type I transmembrane protein predominantly expressed on tissue-resident macrophages. It functions as both an immune checkpoint molecule, negatively regulating T cell activation, and a complement receptor, binding C3b/iC3b to mediate phagocytosis and inhibit the alternative complement pathway. Its restricted expression pattern and dual functions make it a potential therapeutic target in autoimmunity, infectious disease, and cancer.
- Other names
- CRIgZ39Ig
02
Mechanism of action
Inhibition of T cell activation; binding and clearance of C3b/iC3b-opsonized pathogens; inhibition of alternative pathway convertases.
03
Biological functions
Immune regulationNegative regulation of T cell responsesComplement receptor activityPhagocytosisInnate immunityT cell proliferation inhibitionIL2 production inhibitionMaintains T cell unresponsivenessHost defense
04
Disease associations
AutoimmunityInfectious diseaseCancerAtherosclerosis
05
Safety considerations
Potential for immunosuppression if broadly targetedPotential to interfere with complement-mediated pathogen clearance
06
Biomarkers
Marker for tissue-resident macrophages
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