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Target intelligence / Profile preview
V-set domain containing T cell activation inhibitor 1 (VTCN1)
- Target
- VTCN1
- Molecular classification
- B7 family of costimulatory proteins, Immunoglobulin superfamily, Single-pass type I membrane glycoprotein
01
Overview
VTCN1 encodes a protein that acts as an immune checkpoint molecule, primarily functioning as a negative regulator of T-cell-mediated immune responses. It inhibits T-cell activation, proliferation, cytokine production, and the development of cytotoxicity. This regulatory role is crucial for maintaining immune tolerance and preventing autoimmunity. VTCN1/B7-H4 is overexpressed across multiple tumor types where it acts as an immunosuppressive factor within the tumor microenvironment. Targeting VTCN1 may offer therapeutic benefit by modulating immune responses—either enhancing anti-tumor immunity or restoring tolerance in autoimmunity.
- Other names
- B7-H4B7H4B7S1B7XB7h.5PRO1291VCTN1
02
Mechanism of action
Inhibits co-stimulation required for full T-cell activation
03
Biological functions
Immune checkpointNegative regulation of T-cell activationInhibition of T-cell proliferationInhibition of cytokine productionMaintenance of immune tolerance
04
Disease associations
Autoimmune diseasesCancer
05
Safety considerations
Potential for immune-related adverse eventsRisk of exacerbating autoimmune diseases
06
Biomarkers
VTCN1 expression levels in tumor tissueSoluble VTCN1 in serum
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