V-set pre-B cell surrogate light chain 3 (VPREB3)

V-set pre-B cell surrogate light chain 3 (VPREB3) is a small glycoprotein expressed predominantly in early B cell precursors and germinal center B cells. It is a member of the immunoglobulin superfamily, structurally related to other surrogate light chain proteins such as VPREB1 and IGLL1, and typically functions as a component of the pre-B cell receptor complex. VPREB3 associates with immunoglobulin mu heavy chains in the endoplasmic reticulum, modulating their maturation and possibly their transport. While it is not deemed essential for B-cell development, its expression is a reliable marker of certain B-cell malignancies, serving as a valuable immunophenotypic biomarker for the diagnosis and classification of Burkitt lymphoma and some DLBCL subtypes, particularly those harboring c-MYC translocations. Outside hematopoietic tissues, VPREB3 is also found in Purkinje cells of the cerebellum and adrenal zona glomerulosa, but its function in these tissues remains unclear.

Other names

Pre-B lymphocyte protein 3Pre-B lymphocyte 3Pre-B lymphocyte gene 3Protein VPreB3VPREB38HS20N27C7-2UNQ355/PRO619

Null (No drugs target VPREB3 directly, so no mechanism of action is established).