V-type proton ATPase subunit C 2 (ATP6V1C2)

V-type proton ATPase subunit C 2 (ATP6V1C2) is a component of the cytosolic V1 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that acidifies intracellular organelles such as lysosomes, endosomes, and secretory vesicles in eukaryotic cells[1][3][5]. The V1 domain hydrolyzes ATP, providing the energy to drive proton transport via the membrane V0 domain; subunit C acts as a flexible stator, stabilizing the interface between the catalytic and membrane sectors and is necessary for assembly and activity regulation of the complex[2][4][8]. V-ATPase-dependent acidification is essential for key cellular processes including protein degradation, membrane trafficking, receptor-mediated endocytosis, and neurotransmitter loading into synaptic vesicles[1][3][6]. Dysfunction of V-ATPase subunits, including ATP6V1C2, has been linked to diseases such as renal tubular acidosis and may affect other pathologies related to defective organelle acidification[3][6].

Other names

ATPase H+ transporting V1 subunit C2V-ATPase subunit C2VMA5ATP6C2Vacuolar proton pump subunit C2VATC2

Inhibition of proton transport and organelle acidification by blocking V-ATPase function