V-type proton ATPase subunit e 1 (ATP6V0E1)

V-type proton ATPase subunit e 1 (ATP6V0E1) is a membrane-integral protein that forms part of the V0 sector of the vacuolar ATPase (V-ATPase) complex, a multisubunit enzyme responsible for acidifying intracellular compartments in eukaryotic cells[1][2]. The V-ATPase consists of two sectors: the cytosolic V1 domain, which hydrolyzes ATP, and the membrane-embedded V0 domain, which translocates protons across organelle membranes. ATP6V0E1 is essential for proton transport and the acidification required for protein sorting, zymogen activation, endocytosis, synaptic vesicle loading, and cellular homeostasis[1][2][3]. Mutations in ATP6V0E1 have been linked to diseases affecting bone and the nervous system. While the whole V-ATPase is a validated research target for anticancer and neurodegenerative disease drug discovery, ATP6V0E1-specific targeting in clinical settings remains unexplored due to the complex’s essential physiological roles[2][3].

Other names

ATP6HATP6V0EV-ATPase 9.2 kDa membrane accessory proteinV-ATPase M9.2 subunitV-ATPase subunit e 1Vacuolar proton pump subunit e 1ATPase, H+ transporting, lysosomal 9kDa, V0 subunit E1M9.2Vacuolar ATP synthase subunit HV-ATPase subunit e1Vacuolar proton pump H subunitVacuolar proton-ATPase subunit M9.2H(+)-transporting two-sector ATPase, subunit HVma21Vma21p

Inhibitors block proton translocation, leading to impaired organelle acidification, altered vesicular trafficking, and disrupted cellular pH homeostasis.