V-type proton ATPase subunit F (ATP6V1F)

V-type proton ATPase subunit F (ATP6V1F) is a component of the vacuolar (H+)-ATPase (V-ATPase) complex, a multisubunit enzyme responsible for acidifying various intracellular organelles such as endosomes, lysosomes, and the Golgi apparatus, as well as, in some cell types, the plasma membrane[1][2][8]. The V-ATPase is composed of a peripheral cytosolic V1 sector, which includes the F subunit and is involved in ATP hydrolysis, and a membrane-integral V0 sector, which translocates protons[2][3]. Acidification driven by V-ATPase is crucial for processes like protein sorting, zymogen activation, receptor-mediated endocytosis, and neurotransmitter loading into synaptic vesicles[2][1]. The F subunit is necessary for the proper assembly and/or function of the V1 complex[3]. Dysregulation of V-ATPase activity is implicated in several diseases, including cardiomyopathy and Hermansky-Pudlak syndrome, and its broad role in cellular pH regulation means inhibitors risk pleiotropic effects and are not highly selective therapeutics in most current clinical settings[2][1].

Other names

ATPase H+ transporting V1 subunit FATP6S14VATFV-ATPase 14 kDa subunitVacuolar proton pump subunit FVma7Vacuolar ATP synthase subunit FV-ATPase F subunitAdenosinetriphosphatase 14k chainATPase, vacuolar, 14 kD, H(+)-transporting two-sector ATPase, 14kD subunitVacuolar proton pump F subunit

Inhibition of V-type ATPase activity, leading to disruption of proton transport and organelle/compartment acidification