V-type proton ATPase subunit G 3 (ATP6V1G3)

V-type proton ATPase subunit G 3 (ATP6V1G3) is an enzyme subunit that is part of the V1 complex of the vacuolar H+-ATPase (V-ATPase), a multi-subunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPase consists of a cytoplasmic V1 domain, which hydrolyzes ATP, and a transmembrane V0 domain, which translocates protons. The G 3 subunit is one of three G-type subunits forming part of the ATP-hydrolytic V1 domain. Acidification mediated by V-ATPases underlies critical processes such as protein sorting, receptor-mediated endocytosis, enzyme activation, and neurotransmitter storage[1][4][6][8]. There are no drugs or biomarkers specifically targeting this subunit, but the V-ATPase complex as a whole is under investigation as an anticancer and anti-infective target[1][4][8].

Other names

ATP6G3Vma10V-ATPase subunit G 3V-ATPase 13 kDa subunit 3Vacuolar proton pump subunit G 3V-ATPase G3Vacuolar ATP synthase subunit G 3ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3V-ATPase G subunit 3Vacuolar proton pump G subunit 3