V-type proton ATPase subunit G1 (ATP6V1G1)

V-type proton ATPase subunit G1 (ATP6V1G1) is a core component of the V1 domain of the vacuolar-type H^(+)-ATPase (V-ATPase), a multisubunit enzyme transporter complex responsible for the acidification of eukaryotic intracellular organelles such as lysosomes, endosomes, and synaptic vesicles. This acidification is crucial for processes including protein degradation, receptor-mediated endocytosis, protein sorting, and neurotransmitter loading into vesicles. Dysregulation or mutation of ATP6V1G1 is associated with human disease, notably optic atrophy 6; the V-ATPase complex has broader implications in pathologies including neurodegeneration and cancer. ATP6V1G1 does not have specific approved drugs but is researched as part of the V-ATPase complex, especially using inhibitors like bafilomycin A1.

Other names

ATPase H+ transporting V1 subunit G1ATP6GATP6G1ATP6GLATP6JVma10Vacuolar ATP synthase subunit M16V-ATPase subunit G1Vacuolar proton pump subunit G1Vacuolar proton pump subunit M16DKFZp547P234ATPase, H+ transporting, lysosomal (vacuolar proton pump), member JATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1V-ATPase 13 kDa subunit 1Vacuolar H(+)-ATPase subunit G1

Inhibition of proton transport/acidification by V-ATPase; can impact cellular pH, lysosomal function, and vesicle trafficking