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Target intelligence / Profile preview
V virulence antigen of Yersinia pestis (LcrV)
- Target
- LcrV
- Molecular classification
- Protein, Virulence factor, Type III secretion system component, Immunomodulatory protein
01
Overview
LcrV is a multifunctional protein produced by Yersinia pestis, the bacterium responsible for plague. It regulates and facilitates the secretion and translocation of effector proteins (Yops) via the type III secretion system (T3SS). LcrV modulates host immune responses and is a potent protective antigen, making it a vaccine candidate.
- Other names
- LcrVV antigen
02
Mechanism of action
Antibodies against LcrV confer protection against plague. The mechanism of protection does not necessarily block effector translocation but provides immunity.
03
Biological functions
Regulation of type III secretion systemEffector protein translocationImmune modulationBacterial virulenceAdhesion
04
Disease associations
PlagueYersiniosisInfection
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