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Target intelligence / Profile preview
Vaccinia-related kinase 1 (VRK1)
- Target
- VRK1
- Molecular classification
- Enzyme, Ser/Thr protein kinase
01
Overview
Vaccinia-related kinase 1 (VRK1) is a serine/threonine protein kinase involved in cell cycle regulation, nuclear envelope assembly, transcriptional regulation, and DNA damage response. It stabilizes and activates p53, and its overexpression is associated with poor prognosis in several cancers, including hepatocellular carcinoma. VRK1 is considered a potential therapeutic target for cancer and proliferative diseases.
- Other names
- PCH1PCH1Avaccinia related kinase 1VRK serine/threonine kinase 1
02
Mechanism of action
Small-molecule inhibition of kinase activity (in development)
03
Biological functions
Cell cycle regulationNuclear envelope assemblyTranscriptional regulationDNA damage responseCell proliferation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesInhibition may disrupt normal cell cycle and DNA repair processes
06
Biomarkers
VRK1 expression levels as prognostic biomarker in cancer (e.g., HCC)
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