Vacuolar fusion protein MON1 homolog B (MON1B)

Vacuolar fusion protein MON1 homolog B (MON1B) is a cytoplasmic protein involved in multiple steps of intracellular vesicular trafficking, including transport from the endoplasmic reticulum (ER) to the Golgi apparatus and from the Golgi to the plasma membrane[1]. It operates as part of the Mon1-Ccz1 complex, which is essential for endocytic sorting and homotypic fusion of early endosomes, largely by recruiting to EEA1-positive vesicles in conjunction with the docking regulator Numb[3][4][5]. MON1B interacts with cytoplasmic dynein, modulating microtubule-dependent transport of vesicles, and may also influence Golgi apparatus morphology and secretory pathway efficiency[1]. It has a regulatory role in early and late viral transcription, especially during HSV-1 infection through down-regulation of promoter activation[2][5]. Mutations in MON1B have been linked to Joubert syndrome 31 and Brugada syndrome 9, indicating its necessity in proper vesicular traffic for physiological processes[5].

Other names

HSRG1KIAA0872SAND2SRG1HSV-1 stimulation-related gene 1 proteinHSV-I stimulating-related proteinMON1 homolog Bsecretory trafficking associatedMON1 secretory trafficking family member BMON1B