Vacuolar protein sorting 37 homolog A pseudogene

The vacuolar protein sorting 37 homolog A pseudogene (ENSG00000253886) is a non-functional genomic DNA segment highly homologous to the protein-coding VPS37A gene, a component of the ESCRT-I complex involved in intracellular sorting and vesicular trafficking[1]. Like other pseudogenes, it is defined by loss of protein-coding potential but retention of sequence similarity to an ancestral gene[2][5]. Pseudogenes typically do not produce functional proteins or directly participate in cellular processes. While most pseudogenes are presumed non-functional, recent studies suggest some may have regulatory RNA-based roles or impact genome architecture[8]. This pseudogene is not a validated therapeutic target, nor is it implicated in drug interaction or clinical biomarker use. It is mainly relevant in genome annotation and evolutionary studies rather than biomedical applications.\n\nNote: \nIf you require information on the functional gene (**VPS37A**), which is part of the ESCRT-I complex and clinically relevant for diseases (e.g., spastic paraplegia, cancer), refer to gene ENSG00000155975 rather than this pseudogene[1][7].

Other names

vacuolar protein sorting 37 homolog A (S. cerevisiae) pseudogenevacuolar protein sorting 37 homolog A pseudogeneLOC100128833VPS37A pseudogene