Vacuolar protein sorting-associated protein 33B (VPS33B)

Vacuolar protein sorting-associated protein 33B (VPS33B) is a member of the Sec1/Munc18 family and a component of the endolysosomal protein trafficking machinery. It is predominantly associated with late endosomes and lysosomes where it plays a critical role in mediating membrane fusion events required for proper endocytic and protein sorting pathways in mammalian cells. VPS33B is essential for the fusion of late endosomes with lysosomes, recycling of apical proteins especially in polarized cells, and biogenesis of platelet alpha-granules. Mutations in VPS33B are known to cause ARC syndrome, characterized by arthrogryposis, renal dysfunction, and cholestasis. In addition, it has negative regulatory effects on proliferation in some cancer cells. VPS33B functions through its involvement in the HOPS complex, necessary for vesicle tethering and membrane docking in endolysosomal transport processes[1][2][3][5][6].

Other names

FLJ14848KDIDARPFIC12hVPS33Bvacuolar protein sorting 33 homolog Bvacuolar protein sorting 33-like protein B