Vacuolar protein sorting-associated protein 35–Vacuolar protein sorting-associated protein 29 subcomplex (VPS35–VPS29)

The VPS35–VPS29 subcomplex is part of the retromer cargo recognition core, which mediates selective retrieval and recycling of transmembrane proteins from endosomes to the trans-Golgi network or cell surface. VPS35 forms a right-handed α-helical solenoid that wraps around VPS29, whose metallophosphoesterase-like domain acts as a scaffold rather than a functional enzyme. This subcomplex is essential for proper sorting of lysosomal enzymes, maintenance of cellular homeostasis, and is implicated in neurodegenerative disorders when mutated or dysfunctional. It does not form an independent functional unit but requires interaction with VPS26 and membrane-targeting SNX proteins as part of the retromer complex

Other names

VPS35 (for the 35 kDa subunit)VPS29 (for the 29 kDa subunit)Retromer subunitsRetromer core subcomplex

For the research peptides: competitive inhibition or stabilization of retromer-protein interactions (e.g. disruption or mimicry of accessory protein binding to VPS29)