Vacuolar protein sorting-associated protein 37C subunit of ESCRT-I (VPS37C)

Vacuolar protein sorting-associated protein 37C (VPS37C) is a subunit of the ESCRT-I complex, essential for sorting ubiquitinated transmembrane proteins into the internal vesicles of multivesicular bodies[1][2][3][4][5]. VPS37C forms a ternary complex in mammalian cells with Tsg101 and VPS28 and interacts with Hrs and calcium-dependent adaptor proteins such as ALG-2, coordinating protein–protein interactions in response to calcium signaling[2][3][4]. VPS37C is recruited to aberrant endosomes and to the plasma membrane during the budding of enveloped viruses like HIV-1, where its fusion with HIV-1 Gag can bypass the canonical PTAP motif requirement for virion release[1][2][3]. Beyond its role in endosomal sorting and viral budding, VPS37C also regulates erythroid differentiation by stabilizing the EKLF transcription factor, promoting erythroid-specific gene expression[2]. While VPS37C is implicated in pathways exploited by certain viral infections, no established drug interactions, mechanisms of action, biomarkers, or safety concerns have been reported in current reference databases.

Other names

VPS37CVacuolar protein sorting 37 homolog CPML39hVps37CFLJ20847ESCRT-I complex subunit VPS37CVacuolar protein sorting-associated protein 37CESCRT-I subunit