Vacuolar protein sorting-associated protein 37D (VPS37D)

Vacuolar protein sorting-associated protein 37D (VPS37D) is a structural subunit of the ESCRT-I (Endosomal Sorting Complex Required for Transport-I) complex, a key regulator of vesicular trafficking in eukaryotic cells. The ESCRT-I complex is essential for sorting ubiquitinated endocytic cargos into multivesicular bodies (MVBs), which are specialized endosomes involved in cargo sorting, membrane remodeling, and regulation of receptor and protein degradation. VPS37D participates in this process as one of several subunits that form the heterotetrameric ESCRT-I complex. In addition to its canonical role in vesicular transport, defects in VPS37D are associated with Williams-Beuren syndrome and certain developmental disorders. VPS37D is not considered a therapeutic target, receptor, enzyme, transporter, or clinically actionable drug target, and no drugs are currently known to interact with it[2][3][5].

Other names

WBSCR24MGC35352ESCRT-I complex subunit VPS37DWilliams-Beuren syndrome chromosomal region 24 proteinWilliams-Beuren syndrome region protein 24Williams-Beuren syndrome critical region protein 24vacuolar protein sorting 37 homolog DVPS37D subunit of ESCRT-I[2][5]

Not applicable (no drugs known to modulate VPS37D directly)