Target intelligence / Profile preview

Vacuolar-type H⁺-translocating adenosine triphosphatase (V-ATPase)

Target: V-ATPase
Molecular classification: Enzyme, Transporter, ATP-driven proton pump

Overview

Vacuolar ATPases (V-ATPases) are large, multi-subunit enzyme complexes that function as ATP-dependent proton pumps. They are responsible for acidifying intracellular compartments and, in certain specialized cells, the extracellular environment by transporting protons (H⁺ ions) across membranes. V-ATPases play essential roles in processes such as protein degradation, receptor-mediated endocytosis, neurotransmitter loading into synaptic vesicles, and bone resorption. Dysregulation has been linked to cancer progression and drug resistance.

Mechanism of action

Inhibition of proton pumping by V-ATPase

Biological functions

Organelle acidificationProtein degradationNeurotransmitter loadingBone resorptionpH regulationReceptor-mediated endocytosis

Disease associations

Cancer progressionTumor growthTumor invasionMetastasisDrug resistanceOsteopetrosis

Safety considerations

Potential for off-target effects due to ubiquitous expressionAltered pH homeostasis

Beyond the preview

Go deeper on Vacuolar-type H⁺-translocating adenosine triphosphatase (V-ATPase).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Vacuolar-type H⁺-translocating adenosine triphosphatase (V-ATPase).

Explore the full profile