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Target intelligence / Profile preview
Vagal C-fiber (N/A)
- Target
- N/A
- Molecular classification
- Sensory neuron, Nociceptor, Afferent nerve fiber, Unmyelinated nerve fiber
01
Overview
Vagal C-fibers are unmyelinated sensory nerve fibers within the vagus nerve that innervate visceral organs, especially the airways and lungs. They function as nociceptors, detecting noxious stimuli and initiating defensive reflexes like cough. They are potential targets for antitussive therapies and are involved in the pathophysiology of chronic respiratory diseases.
- Other names
- Vagal C fibersBronchopulmonary C-fibersPulmonary C fibersJ-receptorsBronchial C fibersVagal CFRs
02
Mechanism of action
Modulation of C-fiber activity can reduce cough reflex and improve respiratory symptoms.
03
Biological functions
NociceptionSensory transductionReflex initiation (cough, breathing changes)Cardiopulmonary regulationAutonomic nervous system function
04
Disease associations
Chronic coughAirway inflammationRespiratory diseaseSensitization (central and peripheral)AsthmaCOPDIdiopathic Pulmonary Fibrosis
05
Safety considerations
Non-selective targeting may affect normal cardiopulmonary functionPotential for off-target effects on other visceral organsDevelopment of tolerance to therapeutic interventions
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