Target intelligence / Profile preview

Vaginal pH balance

Molecular classification
Other
01

Overview

Vaginal pH balance refers to the moderately acidic environment of the vagina (pH 3.8–4.5 in reproductive-age women) maintained primarily by lactic acid production by *Lactobacillus* species and to a lesser extent by vaginal epithelial metabolism[1][2][5][6]. This acidity serves as a natural barrier against pathogenic microorganisms, supports a healthy vaginal microbiome, and is influenced by age, hormonal status, sexual activity, hygiene practices, and the presence of infection or dysbiosis[1][4][5][8]. While not a target molecule, vaginal pH is a clinically important biomarker for gynecologic health, disease risk (e.g., bacterial vaginosis, candidiasis), and therapeutic monitoring. Loss of normal acidic pH correlates with increased infection risk, inflammation, and reproductive tract pathology[1][2][7].

Other names
Vaginal acidityVaginal pH valueVaginal fluid pH
02

Mechanism of action

Restoration or acidification of vaginal pH by promoting growth of acid-producing bacteria (especially *Lactobacillus* spp.)[5][9]; Direct acidification (lactic acid gel provides exogenous lactic acid); Suppression of overgrowth of pathogenic and anaerobic bacteria by creating an acidic environment[1][2]

03

Biological functions

Protection against pathogenic organisms[1][2][5]Homeostasis of vaginal microbiome[1][2]Maintenance of reproductive tract health[1][2]Prevention of infection (bacterial vaginosis, yeast infection, STIs)[2][5]
04

Disease associations

Infection (bacterial vaginosis, candidiasis, STIs)[1][2][5]Other (pregnancy outcomes: preterm birth risk; postmenopausal changes)[1][2][7]
05

Safety considerations

Disruption of vaginal pH (higher pH) can increase risk of infection, BV, or adverse pregnancy outcomes[1][2][7]Overuse of pH-altering products (e.g., douches, alkaline-based washes) may disturb flora and pH balance[1][6]
06

Interacting drugs

Vaginal acidifying agents (lactic acid gel)

2 more in the full profile.

07

Biomarkers

Vaginal pH (measured by test strips or clinical swabs; physiological range: 3.8–4.5 in reproductive age women)[1][2][9]Presence/absence of *Lactobacillus* species (especially *L. crispatus*, *L. iners*, *L. gasseri*, *L. jensenii*)[2][5]

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