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Target intelligence / Profile preview
Vancomycin-Resistant Enterococcus (VRE)
- Target
- VRE
- Molecular classification
- Bacteria, Gram-positive bacteria
01
Overview
Vancomycin-resistant Enterococcus (VRE) refers to strains of the genus *Enterococcus* that have developed resistance to vancomycin, an antibiotic commonly used to treat serious infections. Resistance is primarily mediated by acquired gene clusters that alter the target site for vancomycin within the bacterial cell wall synthesis pathway.
02
Mechanism of action
Resistance is mediated by acquired gene clusters (vanA and vanB) that modify peptidoglycan precursors, reducing vancomycin binding affinity.
03
Biological functions
ColonizationInfectionAntibiotic resistance
04
Disease associations
InfectionAntibiotic resistanceHospital-acquired infection
05
Safety considerations
Limited treatment options due to multidrug resistanceSpread in healthcare settingsRisk of serious infections in immunocompromised individuals
06
Interacting drugs
Vancomycin
3 more in the full profile.
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