Variant U1 small nuclear RNA 15 (RNVU1-15)

Variant U1 small nuclear RNA 15 (RNVU1-15) is part of the family of U1 snRNA variants (vU1 snRNAs), non-coding RNAs that are closely related in sequence and function to canonical U1 snRNA. U1 snRNA is a key component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP), which forms part of the spliceosome and is essential in the recognition of the 5′ exon-intron boundary during pre-mRNA splicing[1]. The RNVU1-15 gene is one of numerous U1 snRNA variant genes present in the human genome, typically found in segmental duplication regions, and exhibits high sequence similarity to canonical U1 snRNA[2]. Its specific functional role, expression, and clinical implications are still under investigation. Variability in these loci contributes to genomic diversity and complexity, and may predispose to certain genetic diseases, though it is not considered a classical drug target[2].

Other names

vU1.15RNU1-66vU1.16RNU1-121RNVU1-16RNA, variant U1 small nuclear 16