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Target intelligence / Profile preview
Varicella zoster virus (None)
- Target
- None
- Molecular classification
- Virus, dsDNA virus, Herpesvirus
01
Overview
Varicella zoster virus (VZV), also known as human herpesvirus 3 (HHV-3), is a member of the Herpesviridae family and causes two major diseases: varicella (chickenpox) during primary infection and herpes zoster (shingles) upon reactivation from latency. It is a highly contagious, human-restricted DNA virus. After recovery from chickenpox, VZV establishes lifelong latency in sensory nerve ganglia. Reactivation leads to herpes zoster (shingles).
- Other names
- Human herpesvirus 3HHV-3
02
Mechanism of action
Acyclovir, valacyclovir, and famciclovir are antiviral drugs that inhibit viral DNA polymerase. Varicella vaccine stimulates an immune response to prevent VZV infection.
03
Biological functions
Viral replicationEstablishment of latencyImmune evasionCell entry and fusion
04
Disease associations
Chickenpox (varicella)Shingles (herpes zoster)Postherpetic neuralgiaVasculopathyStroke
05
Safety considerations
Antiviral resistanceVaccine side effects (rare)Immunocompromised individuals at higher risk for severe disease
06
Interacting drugs
Acyclovir
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