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Varicella-zoster virus antigen (Oka strain) (VZV Oka strain antigen)

Target: VZV Oka strain antigen
Molecular classification: Viral antigen, Envelope glycoprotein

Overview

The Varicella-zoster virus (VZV) Oka strain is a live, attenuated form of VZV used as the antigen in varicella (chickenpox) and herpes zoster (shingles) vaccines. It induces an immune response, primarily targeting envelope glycoprotein E (gE), leading to protection against VZV infection. Attenuation is achieved through serial cell culture passages, resulting in reduced virulence while maintaining immunogenicity.

Other names: Oka/Merck antigenLive attenuated VZV Oka strainVaricella-zoster virus Oka straingE (glycoprotein E) of VZV OkaORF68 of VZV Oka

Mechanism of action

Stimulates the production of neutralizing antibodies and cell-mediated immunity against VZV upon administration as a live attenuated vaccine. This prevents or mitigates subsequent infection by wild-type VZV.

Biological functions

Induction of immune responseViral entryViral replicationCell-to-cell transmission

Disease associations

Prevention of varicella (chickenpox)Prevention of herpes zoster (shingles)Infection

Safety considerations

Reactivation of latent VZV (rare)Potential for transmission of vaccine strain (rare)Contraindicated in immunocompromised individualsLocal injection site reactions

Interacting drugs

Varicella vaccines

1 more in the full profile.

Biomarkers

Anti-VZV antibody titersVZV-specific T cell responses

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