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Varicella-zoster virus DNA polymerase
- Molecular classification
- Enzyme, DNA polymerase
01
Overview
Varicella-zoster virus (VZV) DNA polymerase is a key viral enzyme responsible for replicating the VZV genome during infection. It is essential for viral replication and the production of infectious progeny. The enzyme consists of a catalytic subunit (ORF28) and an accessory/processivity factor (ORF16). Its activity is inhibited by antiviral drugs like acyclovir, making it a prime target for treating VZV infections.
02
Mechanism of action
Chain terminator after phosphorylation, inhibiting DNA elongation
03
Biological functions
DNA replicationViral genome replication
04
Disease associations
InfectionChickenpoxShingles
05
Interacting drugs
Acyclovir
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