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Target intelligence / Profile preview
Varicella-zoster Virus Glycoprotein Antigens (VZV Glycoproteins)
- Target
- VZV Glycoproteins
- Molecular classification
- Viral Glycoprotein, Viral Structural Protein, Fusion protein
01
Overview
Varicella-zoster virus (VZV) glycoprotein antigens are structural proteins embedded in the viral envelope, playing essential roles in viral entry, cell-to-cell spread, immune evasion, and pathogenesis. The most prominent VZV glycoproteins include glycoprotein E (gE), glycoprotein B (gB), and the gH/gL heterodimer. These glycoproteins are major targets for neutralizing antibodies and are used in diagnostic assays and vaccine development.
- Other names
- VZV envelope glycoproteinsgEgBgH/gL complexVaricella-zoster virus antigens
02
Mechanism of action
Neutralization of viral entry, inhibition of cell-to-cell spread
03
Biological functions
Viral entryCell-to-cell spreadImmune evasionMembrane fusion
04
Disease associations
ChickenpoxShinglesVaricella-zoster virus infection
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