Target intelligence / Profile preview

Varicella Zoster Virus Glycoprotein E (gE)

Target: gE
Molecular classification: Glycoprotein, Type I membrane protein

Overview

Varicella zoster virus glycoprotein E (gE) is a multifunctional, type I membrane glycoprotein encoded by the VZV genome (ORF68). It is the most abundant glycoprotein on the surface of infected cells and within virion envelopes. gE is indispensable for viral replication, cell-to-cell spread, and envelopment, making it essential for VZV viability. It interacts with the insulin-degrading enzyme (IDE) receptor and is the sole antigen component in the Shingrix vaccine.

Mechanism of action

Neutralization of viral entry and cell-to-cell spread by vaccine-induced antibodies

Biological functions

Viral replicationCell-to-cell spreadViral envelopmentViral entry/attachmentFc receptor activity

Disease associations

InfectionVaricella (chickenpox)Herpes zoster (shingles)

Interacting drugs

Shingrix (vaccine-induced antibodies)

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