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Target intelligence / Profile preview
Varicella-zoster virus glycoproteins (VZV glycoproteins)
- Target
- VZV glycoproteins
- Molecular classification
- Viral glycoprotein, Envelope protein
01
Overview
Varicella-zoster virus encodes several envelope-associated glycoproteins—most notably the essential trio of gB, gH, and gL—that orchestrate attachment to host cells, trigger membrane fusion events needed for infection/spread, undergo significant post-translational modification including N-glycosylation/phosphorylation/ubiquitination during biosynthesis/trafficking through ER/Golgi pathways before incorporation into new virions. These molecules serve as key determinants of viral pathogenicity/tropism/immunogenicity.
- Other names
- VZV envelope glycoproteinsgBgHgLgEgKgIgCgMgN
02
Mechanism of action
Neutralizing antibodies target conformational epitopes on surface-exposed glycoproteins.
03
Biological functions
Viral entryMembrane fusionCell-to-cell spreadImmune evasionReplicationAttachment
04
Disease associations
Chickenpox (varicella)Shingles (herpes zoster)VZV infection
05
Safety considerations
Mutations affecting key domains can alter viral infectivity, tissue tropism, and pathogenicity.
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