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Target intelligence / Profile preview
Variola Virus
- Molecular classification
- Virus, DNA Virus, Poxviridae, Orthopoxvirus
01
Overview
The variola virus is the causative agent of smallpox, a highly contagious and often deadly disease that has been eradicated globally since 1977. It is a large, brick-shaped DNA virus that replicates entirely within the cytoplasm. Transmission occurs via respiratory droplets or contaminated materials. While eradicated, it remains a potential threat as a biological weapon.
- Other names
- Smallpox VirusOrthopoxvirus variola
02
Mechanism of action
Vaccinia virus vaccine provides immunity. Cidofovir and brincidofovir are antiviral agents that inhibit viral DNA polymerase. Tecovirimat inhibits the VP37 protein, preventing the formation of extracellular virus.
03
Biological functions
ReplicationTranscriptionImmunomodulationHost infectionCell-to-cell spread
04
Disease associations
InfectionSmallpox
05
Safety considerations
Vaccinia virus vaccine can cause adverse reactionsPotential for use as a biological weaponAntiviral resistance
06
Interacting drugs
Vaccinia virus vaccine (live)
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