Various metabolic enzymes requiring B-vitamins as cofactors

The term refers to a broad group of metabolic enzymes that utilize B-vitamins (e.g., thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, cobalamin) as essential cofactors. These enzymes are involved in critical biochemical pathways such as glycolysis, the tricarboxylic acid cycle, amino acid and fatty acid metabolism, nucleotide and neurotransmitter biosynthesis, and methylation reactions. B-vitamin-dependent enzymes include, among others, pyruvate dehydrogenase, transaminases, methylmalonyl-CoA mutase, methionine synthase, and dihydrofolate reductase. Dysregulation by deficiency, overactivity, or pharmacologic inhibition can result in metabolic disturbances, some of which are associated with major diseases, including anemia, cardiovascular disease, and certain cancers. Due to the broadness and nonspecificity, this listing does not qualify as a single actionable target in a drug development or clinical context. If you are seeking structured information on a specific enzyme (for example, “pyruvate dehydrogenase” or “methionine synthase”), please provide the enzyme’s precise name for targeted and canonicalized data.

Inhibition or modulation of enzyme activity by affecting B-vitamin-dependent cofactor pathways (e.g., inhibition of NAD biosynthesis, folate metabolism inhibition). Nutritional supplementation restoring function if deficiency present.