Vascular cell adhesion molecule 1 (VCAM-1) mRNA (VCAM-1 mRNA)

Vascular cell adhesion molecule 1 (VCAM-1) mRNA is the messenger RNA transcript that encodes the VCAM-1 protein, a member of the immunoglobulin superfamily primarily expressed on activated vascular endothelial cells (UniProt: P19320). The expression of VCAM-1 mRNA is significantly upregulated by pro-inflammatory cytokines like TNF-alpha, leading to the recruitment of leukocytes to the vascular wall, a process central to the pathogenesis of atherosclerosis and chronic inflammatory diseases (PubMed: 10498383). As a therapeutic target, VCAM-1 mRNA is approached using antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) to achieve post-transcriptional gene silencing. By degrading the mRNA or preventing its translation, these therapies aim to reduce the density of VCAM-1 on the cell surface, thereby limiting leukocyte adhesion and attenuating tissue inflammation (PubMed: 11592945). While clinical development has faced hurdles regarding targeted delivery to the endothelium, experimental agents like ISIS 18133 have shown promise in preclinical studies for treating cardiovascular and autoimmune conditions. Monitoring soluble VCAM-1 levels often serves as a biomarker for the efficacy of such interventions in reducing endothelial activation.

Other names

CD106 mRNAVascular cell adhesion protein 1 mRNAINCAM-100 mRNAVCAM1 mRNA

Antisense-mediated mRNA degradation or RNA interference (RNAi) leading to post-transcriptional gene silencing.