Vascular endothelial function improvement

"Vascular endothelial function improvement" refers to the enhancement or restoration of the normal physiological activities of the vascular endothelium, the thin cell layer lining blood vessels. This state is marked by improved balance between vasodilators (notably nitric oxide), vasoconstrictors, and other mediators that regulate vascular tone, thrombosis, inflammation, and permeability. Interventions that improve endothelial function are pursued as preventive and therapeutic strategies for cardiovascular and metabolic diseases, since endothelial dysfunction is a key early event in atherosclerosis, hypertension, diabetes, and other chronic conditions

Other names

improvement of endothelial functionendothelial protectionenhancement of vascular endothelial health

Increase nitric oxide (NO) bioavailability - Enhance endothelial nitric oxide synthase (eNOS) expression - Reduce oxidative stress - Inhibit endothelial inflammation (e.g., via KLF2/KLF4) - Modulate prostacyclin, EDHF, and endothelin signaling