Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Vascular endothelial growth factor A gene promoter
- Molecular classification
- Gene regulatory region, Promoter, Cis-regulatory element
01
Overview
The vascular endothelial growth factor A gene promoter is a DNA sequence upstream of the VEGFA gene that regulates its transcription. This promoter contains binding sites for multiple transcription factors, including hypoxia-inducible factor 1 alpha (HIF-1α), and is sensitive to both physiological and pathological stimuli such as hypoxia, inflammation, and oncogenic signaling. Genetic polymorphisms in the promoter can affect the levels of VEGFA expression, influencing susceptibility or progression of diseases that depend on angiogenesis, including cancer and vascular disorders. The promoter is not itself a therapeutic target, but its activity underlies the pathophysiologic relevance and druggability of the VEGFA signaling axis.
- Other names
- VEGFA gene promoterVEGF-A promotervascular endothelial growth factor A promoter
02
Biological functions
Regulation of VEGFA gene expressionResponse to hypoxiaModulation of angiogenesis through transcriptional control
03
Disease associations
Cancer (through effects on VEGFA expression)Cardiovascular disease (via vascular growth regulation)Diabetic microvascular complications (influence on vessel permeability and growth)Inflammation (indirect, through regulation of VEGFA)
04
Biomarkers
VEGFA gene promoter polymorphisms (e.g., -460T/C, -2578C/A, -2549I/D) may serve as *genetic biomarkers* for VEGFA expression and related disease susceptibility
Beyond the preview
Go deeper on Vascular endothelial growth factor A gene promoter.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Vascular endothelial growth factor A gene promoter.