Vascular endothelial growth factor A messenger RNA 3′ untranslated region (VEGF mRNA 3′UTR)

The Vascular endothelial growth factor A messenger RNA 3′ untranslated region (VEGF mRNA 3′UTR) is a critical regulatory segment of the transcript encoding VEGF-A, the primary driver of angiogenesis (Source 1.3.2). This region contains numerous cis-acting elements, including AU-rich elements (AREs) and binding sites for microRNAs such as miR-101 and miR-503, as well as RNA-binding proteins like HuR and hnRNP L (Source 1.2.1, 2.1.2). These elements orchestrate the stability and translational efficiency of the mRNA, particularly in response to environmental cues like hypoxia or inflammation (Source 1.3.1). In many cancers, the 3′UTR is exploited to overexpress VEGF, promoting tumor vascularization and metastasis, while in ischemic diseases, it can be targeted to stabilize the mRNA and enhance therapeutic angiogenesis (Source 1.2.5, 1.3.4). Drug development efforts have focused on this region using small molecules like PTC299 (Emvododstat), which was identified via its ability to inhibit UTR-mediated translation, and various RNA-targeted modalities such as antisense oligonucleotides and microRNA mimics (Source 1.3.1, 2.3.2). Furthermore, optimized 3′UTR sequences are incorporated into synthetic mRNA drugs like AZD8601 to ensure robust and sustained protein production in clinical settings (Source 1.3.5).

Other names

VEGF 3'UTRVEGFA 3'UTRVascular endothelial growth factor A 3' untranslated regionVEGF 3' untranslated regionVEGF-A 3'UTR

Modulation of mRNA stability and translational efficiency through interaction with cis-acting regulatory elements, including AU-rich elements and microRNA binding sites.