Vascular endothelial growth factor A messenger RNA microRNA-205 response element (VEGFA miR-205 RE) (VEGFA miR-205 RE)

The miR-205 response elements on VEGFA mRNA are specific regulatory sequences located within the 3' untranslated region (3' UTR) of the Vascular Endothelial Growth Factor A (VEGFA) transcript (Wu et al., 2016, PMID: 26848621). These elements serve as the primary binding sites for microRNA-205 (miR-205), which acts as a post-transcriptional repressor of VEGFA expression. By recruiting the RNA-induced silencing complex (RISC), miR-205 binding leads to either the degradation of the VEGFA mRNA or the inhibition of its translation into protein (Hu et al., 2016, PMID: 27167194). This interaction plays a critical role in controlling angiogenesis, as VEGFA is a major driver of blood vessel formation and vascular permeability. In many cancers, such as breast and prostate cancer, miR-205 is frequently downregulated, resulting in the loss of this inhibitory control and subsequent VEGFA-mediated tumor vascularization (Greene et al., 2010, PMID: 20802488). Similarly, in ocular diseases like neovascular age-related macular degeneration, modulating these response elements offers a potential therapeutic pathway to reduce pathological vessel growth (Yan et al., 2018, PMID: 30128485). Experimental therapies, including miR-205 mimics and antisense oligonucleotides, are being explored to target these sites to restore normal VEGFA regulation.

Other names

VEGFA 3' UTR miR-205 binding sitemiR-205-5p response element on VEGFA mRNAVEGFA microRNA response elementVEGFA MRE

Binding of microRNA mimics to the response element recruits the RNA-induced silencing complex (RISC), leading to mRNA degradation or translational inhibition of VEGFA.