Vascular endothelial growth factor A mRNA (VEGF-A mRNA)

Vascular endothelial growth factor A mRNA (VEGF-A mRNA) is the mature messenger RNA transcript produced from the VEGFA gene, coding for the protein VEGF-A. This mRNA is pivotal in the regulation of angiogenesis, vascular permeability, and cell survival by facilitating translation of VEGF-A protein, a critical regulator of endothelial cell function and blood vessel formation. Clinical and experimental therapies have targeted VEGF-A mRNA using modified mRNA constructs (to increase angiogenesis in ischemic tissues) or nucleic acid-based inhibitors (antisense, siRNA) to dampen pathological blood vessel growth. Its precise post-transcriptional and translational regulation underlies the critical balance between physiological tissue repair and pathological angiogenesis in disease settings ranging from cancer to cardiovascular disease[3][6][7].

Other names

VEGFA mRNAVascular permeability factor mRNA (historical)VEGF mRNA (non-specific; "VEGF" may refer to family)

For mRNA-based therapies (e.g., AZD8601): delivery of modified VEGF-A mRNA for transient in situ translation and increased local VEGF-A protein expression, inducing therapeutic angiogenesis[6][7] For oligonucleotides/siRNAs (experimental): sequence-specific binding to VEGF-A mRNA to inhibit translation or promote degradation, reducing VEGF-A protein[3]