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Target intelligence / Profile preview
Vascular Endothelial Growth Factor A Receptor (VEGFA Receptor)
- Target
- VEGFA Receptor
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
The Vascular Endothelial Growth Factor A Receptor refers mainly to two closely related receptor tyrosine kinases—VEGFR‐1/Flt‐1 and especially VEGFR‐2/KDR—that mediate nearly all biological actions triggered by binding of their principal ligand VEGF‐A, including new blood vessel formation under both normal physiological conditions and pathological states like cancer.
- Other names
- VEGFR-1Flt-1VEGFR-2KDRFlk-1
02
Mechanism of action
Monoclonal antibodies against VEGF-A ligand or small-molecule inhibitors targeting receptor kinase activity.
03
Biological functions
AngiogenesisVascular permeabilityEndothelial cell proliferationEndothelial cell migrationEndothelial cell survivalSignal transduction
04
Disease associations
CancerDiabetic retinopathyAge-related macular degenerationRheumatoid arthritisPsoriasisAtherosclerosisMicrovascular complications in diabetes
05
Safety considerations
Resistance mechanisms to anti-angiogenic therapiesPotential for off-target effects of kinase inhibitorsIncomplete efficacy in some tumors
06
Interacting drugs
Bevacizumab
2 more in the full profile.
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